iStock_000001809500SmallApproximately 1:10 individuals that experience a significant life stressor develop post-traumatic stress disorder (PTSD), and PTSD continues to be a major health concern of the Veteran patient population. VBRI-supported researchers are trying to understand what vulnerability factors contribute to the development of PTSD. Through clinical and pre-clinical studies, personality factors, such as a behaviorally inhibited temperament, have been found to be associated with different patterns of cognitive functioning, which may contribute to symptoms of PTSD following a trauma. VBRI investigators have also used pre-clinical models to determine that reduced levels of selective brain proteins may be the cause of the differences in cognitive functioning, and they may be novel biological targets that could help support more efficient and effective cognitive-behavioral therapies.

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